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. 2021 Feb 22;30(8):727–738. doi: 10.1093/hmg/ddab053

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© The Author(s) 2021. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Estimates of SNP-based heritability and GE-based heritability for outcomes in UKB. PRS indicates the SNP-heritability as estimated using PRS association results in AVENGEME. GeRS indicates the GE-based heritability as estimated using GeRS association results in AVENGEME. GeRS (coloc) indicates the GE-based heritability as estimated using GeRS when restricted to genes with colocalization PP4 > 0.8. The value above each bar indicates the proportion of SNP-based heritability accounted for by cis-regulated expression.