Table 2.
Risk of Survival and Surrogate Clinical Endpoints.
| Ref | Risk of death (RR [95%CI]) | Risk of ICU admission (RR [95%CI]) | Risk of invasive mechanical ventilation (RR [95%CI]) | Risk of secondary infection (RR [95%CI]) |
|---|---|---|---|---|
| Observational (historical control) | 0.28 [0.16, 0.49] | NA | 0.74 [0.40, 1.37] | 2.18 [0.68, 6.98] |
| Observational (matched) | 0.68 [0.53, 0.87] | 2.25 [1.17, 4.33] | 0.77 [0.33, 1.80] | 1.12 [0.77, 1.62] |
| Observational (concurrent control) | 1.10 [0.77, 1.56] | 1.91 [0.47, 7.69] | NA | 1.27 [0.85, 1.89] |
| Randomized controlled trials | 1.18 [0.57, 2.44] | 0.80 [0.49, 1.33] | 0.92 [0.21, 4.10] | 0.26 [0.03, 2.28] |
| Total events | 0.74 [0.59, 0.93] | 1.40 [0.64, 3.06] | 0.83 [0.57, 1.22] | 1.30 [0.97, 1.74] |
RR relative risk, NA not available.