Fig. 4.

Public antibody clonotypes shared by convalescent COVID-19 patients. Public antibody clonotypes from paired immunoglobulin heavy chains and light chains shared between CV2 and CV3 (a), CV3 and CV4 (b), CV3 and CV5 (c), respectively. The list of particular immunoglobulin variable genes was showed on the right. Paired public antibody clonotypes were defined based on their shared VH and JH germline segments, the same VK/VL and JK/JL, and the highly similar CDRH3 amino acid sequences with 80% or greater amino acid identity. Immunoglobulin heavy chains of public antibody shared between CV2 and CV3 (d), CV3 and CV4 (e), CV3 and CV5 (f), respectively. The heavy chains with the same IGHV and IGHJ genes and 80% or greater similarities of CDRH3 amino acid sequences were identified as heavy chains public antibody clonotypes. g Public antibody clonotypes from heavy chains shared among COVID19_scRNAseq (COVID19 patients from single cell RNA sequencing), COVID19_NGS_2, COVID19_6 and COVID19_NGS_12(COVID19 patients from next-generation sequencing)