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. 2021 May 17;2021(5):CD009858. doi: 10.1002/14651858.CD009858.pub3

1. Category of overall risk of bias.

Risk of bias Interpretation Within a study Across studies
Low risk of bias Plausible bias unlikely to seriously alter the results Low risk of bias for all key domains Most information is from studies at low risk of bias
Unclear risk of bias Plausible bias that raises some doubt about the results Unclear risk of bias for ≥ 1 key domains Most information is from studies at low or unclear risk of bias
High risk of bias Plausible bias that seriously weakens confidence in the results High risk of bias for ≥ 1 key domains The proportion of information from studies at high risk of bias is sufficient to affect the interpretation of results