Figure 4.

Relationship between VCAN and immune infiltration. (A) CIBERSORT was used to analyze the immune infiltration of 22 immune cells. (B) 7 immune cells (T cells CD8+, T cells CD4 memory activated, macrophages M0, macrophage M1, mast cells resting, mast cells activated, neutrophils) were supposed to have different levels of infiltration between high/low immunity group. (C–E) According to the TIMER database, 3 immune cells (T cell CD8+, macrophages M1, mast cell activated) were suggested to have a significant correlation after the adjustment of purity. (F) Macrophage M1 had significant high expression in mutated VCAN group, which indicated that mutation VCAN may induce the high immune infiltration of macrophage M1. (G, H) According the TISIDB, macrophage and mast cells were supposed to have significant correlation with VCAN expression