Figure 5.
The value of VCAN in immune therapy. (A) In TISIDB, VCAN had the most high expression in TGF‐b dominant type of gastric cancer significantly (p = 9.14 × 10−3). (B, C) After analyzing in TISIDB, VCAN was significantly correlated with two immune biomarkers in immunotherapy (PDCD1LG2, ENTPD1). (D, E) The correlation between two biomarkers and VCAN were verified through GEPIA which demonstrated that VCAN was significantly correlated with two genes indeed. (F, G) According to the result from TIMER database, VCAN had a significant correlation with two genes after the adjustment of tumor purity. (H, I) VCAN was found to be the target of the hyaluronic acid. IFN, interferon; TGF, tumor growth factor