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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Inflamm Res. 2021 Feb 10;70(3):359–373. doi: 10.1007/s00011-021-01443-4

Fig. 6. Assessment of LMP in chronic model.

Fig. 6

Balb/c mice were instilled with either DM-only, MWCNT, or SiO2 once a week at weeks 0, 1, 2, 3 while on the normal mouse chow and at week 4 were put on a control or 1% DHA diet for 12 weeks. LMP was assessed through detection of (a) IL-1β release directly from AMs ex vivo, (b) cathepsin release within the LLF, and (c) cathepsin B release within the LLF. Data presented as mean ± SEM, n=4–7. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 compared to DM, + compared to different diet within the same exposure group. Analyses were done with log-transformed data. CTS; cathepsin