Fig. 8. Impact of particle exposure and DHA treatment on macrophage phenotype in chronic model.
Balb/c mice were instilled with either DM-only, MWCNT, or SiO2 once a week at weeks 0, 1, 2, 3 while on the normal mouse chow and at week 4 were put on a control or 1% DHA diet for 12 weeks. Relative gene expression of control diet MWCNT or SiO2 mice were normalized to control diet DM-only mice for assessment of particle effect in (a) lung and (c) spleen tissue. Relative gene expression of 1% DHA diet mice were normalized to corresponding control diet mice for assessment of diet effect in (b) lung and (d) spleen tissue. Each bar within the heat maps consist of 5–7 mice for lung tissue and 4–6 mice for spleen tissue
