Table 4.

Plasma cytokine and chemokine concentrations at median 22-months post-infection.

Analyte	CHIKV cases n=33 in pg/ml	Controls n=10 in pg/ml	p-value
Cytokines
Interleukin-1α (IL-1α)	1.29 (0.58–3.82)	1.42 (0–4.93)	0.39
Interleukin-1β (IL-1β)	0.27 (0.17–0.69)	0.20 (0.10–0.28)	0.10
Interleukin-2 (IL-2)	1.70 (1.25–2.89)	2.06 (1.70–2.89)	0.12
Interleukin-4 (IL-4)	1.08 (0.76–2.80)	1.31 (0.61–2.51)	0.80
Interleukin-6 (IL-6)	1.69 (1.01–3.18)	1.32 (0.73–1.69)	0.09
Interleukin-10 (IL-10)	1.80 (1.29–2.56)	1.92 (1.29–2.08)	0.85
Interleukin-12 (IL-12/p40)	111 (92.0–137)	116 (87.4–161)	0.55
Interleukin-12 (IL-12/p70)	1.91 (1.37–6.20)	1.78 (1.05–6.79)	0.81
Interleukin-15 (IL-15)	2.55 (2.01–2.97)	2.64 (1.89–3.32)	0.63
Interleukin-17α (IL-17a)	7.81 (6.35–9.19)	7.2 (4.95–8.44)	0.41
Interferon-γ (IFN-γ)	7.44 (3.92–16.1)	6.7 (3.92–13.0)	0.82
GM_CSFa	0.93 (0.60–1.30)	0.80 (0.32–1.15)	0.55
Chemokines
Eotaxin	101 (68.0–136)	104 (65.0–134)	0.93
MIP-1αb	23.9 (18.2–36.3)	27.6 (23.8–37.9)	0.22
IP-10	162 (123–227)	153 (133–197)	0.67
MCP-1d	123 (88.3–140)	106 (87.5–144)	0.75
MIP-1βe	46.6 (33.8–56.5)	38.13 (32.7–54.0)	0.40
Interleukin-8 (IL-8)	7.91 (6.15–16.9)	6.7 (5.44–11.4)	0.12

^aGranulocyte-Monocyte CSF

^bMacrophage inhibitory protein

^cInterferon-γ induced Protein

^dMonocyte chemotactic protein-1

^eMacrophage inhibitory protein