Figure 4. Effect of miR-146 on fibroblasts proliferation and relative levels of pro-inflammatory cytokines in isolated primary human epidural fibroblasts. A. The transfection of miR-146 mimic significantly increased the expression of miR-146, while the transfection of miR-146 inhibited the expression of miR146. ***P < 0.001 relative to control (untransfected cells). B. The proliferation of fibroblasts was promoted by the overexpression of miR-146 and suppressed by the knockdown of miR-146. *P < 0.05 relative control. C. The relative levels of IL-1 beta, IL-6, and TNF-α increased by the overexpression of miR-146 and reduced by the silencing of miR-146. ***P < 0.001 relative to control.