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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Ticks Tick Borne Dis. 2020 Dec 13;12(2):101638. doi: 10.1016/j.ttbdis.2020.101638

Fig. 2.

Fig. 2.

An overview of the transcriptional response of early localized infection. Infection occurs by the transmission of B. burgdorferi s.l. through the bite of a tick and is localized within the skin of the host. Following infection, several resident cells detect and initiate a transcriptional profile in response to the pathogen. Dermal fibroblasts aid in the recruitment of lymphocytes and produce matrix metalloproteinases that leads to the degradation of the extracellular matrix. Monocytes and macrophages initiate phagocytosis and play key roles in the promotion of inflammation, and activation and attraction of leukocytes. Similarly, dendritic cells aid in peripheral immune cell chemotaxis and promote their differentiation and activation. Infection may lead to an impaired migration of dendritic cells to lymph nodes. Created with BioRender.com.