Table 3.
Effect of PIC on markers of hepatic and renal mitochondrial function in rats exposed to RES or γ-radiation.
| Parameters | Control | PIC | RES | RES + PIC | IR | IR + PIC |
|---|---|---|---|---|---|---|
| Hepatic mitochondrial function | ||||||
| ATP (µmol/mg protein) | 0.93 ± 0.45a | 0.97 ± 0.23a | 0.25 ± 0.19b | 0.68 ± 0.05c | 0.37 ± 0.04d | 0.87 ± 0.16e |
| Complex I (µmol NADH/min/mg protein) | 79 ± 10a | 78 ± 11a | 58 ± 6b | 68 ± 15c | 22 ± 5d | 57 ± 9b |
| Renal mitochondrial function | ||||||
| ATP (µmol/mg protein) | 0.98 ± 0.07a | 1.05 ± 0.06a | 0.39 ± 0.26b | 0.71 ± 0.15c | 0.47 ± 0.06d | 0.90 ± 0.45a |
| Complex I (µmol NADH/min/mg protein) | 68 ± 13a | 69 ± 9a | 50 ± 7b | 58 ± 14c | 19 ± 5d | 49 ± 10b |
Data are presented as means ± SD (n = 8). Groups with different letters are significantly different, at P ⩽ 0.05. Groups with similar letters are not significantly different, at P ⩽ 0.05.