Table 3.
Comparison of administrations, interventions, and secondary endpoints
| Items | ICUS group (n = 50) | CON group (n = 44) | p value |
|---|---|---|---|
| Vasoactive and inotropic administrations | |||
| Maximum dose of norepinephrine,* µg/kg/minute | 0.75 (0.20–2.0) | 1.00 (0.35–2.0) | 0.15 |
| Dobutamine | 4 (8.2) | 2 (4.4) | 0.68 |
| Vasopressin | 1 (2.0) | 4 (8.89) | 0.19 |
| Others# | 8 (16.3) | 5 (11.1) | 0.49 |
| Cardiac dysfunction | 9 (18.4) | 9 (20.0) | 0.80 |
| CRRT | 24 (49.0) | 26 (57.8) | 0.58 |
| PiCCO | 11 (22.5) | 10 (22.2) | 0.97 |
| Secondary outcomes | |||
| Lactate clearance rate$ | 0.13 (−0.34–0.41) | 0.17 (−0.23–0.44) | 0.78 |
| Time to lactate normalization, hours | 18.5 (7.3–69.0) | 19.0 (11.5–213.0) | 0.61 |
| Duration of vasopressor use, hours | 48.0 (24.0–83.5) | 69.0 (34.0–97.9) | 0.08 |
| ICU stay, hours | 108.0 (63.5–286.8) | 130.1 (96.0–296.7) | 0.38 |
| Duration of mechanical ventilation, hours | 60.00 (18.7–152.6) | 62.0 (24.0–120.0) | 0.72 |
Data are presented as n (%) or median (interquartile range).
*The maximum dose did not include the use of vasopressors at the time of death.
#Others included digitalin, natriuretic peptide, adrenaline, dopamine, and esmolol.
$Lactate clearance rate = (first measurement within 1 hour after ICU admission − first measurement 6 hours after initial therapy) / first measurement within 1 hour after ICU admission.
ICUS, integrated cardiopulmonary ultrasonography; CON, conventional; CRRT, continuous renal replacement therapy; PiCCO, pulse index continuous cardiac output; ICU, intensive care unit.