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. 2021 May 3;11:581172. doi: 10.3389/fonc.2021.581172

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Copyright © 2021 Rasti, Madjd, Saeednejad Zanjani, Babashah, Abolhasani, Asgari and Mehrazma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical (IHC) Analysis of Nuclear SMAD4 Expression in Different 707 Renal Cell Carcinoma (RCC) Samples. RCC samples expressed SMAD4 at various levels. SMAD4 expression in clear cell RCC at various levels: weak (A), moderate (B), and strong (C). Moderate expression of SMAD4 in chromophobe RCC (D) and strong expression of SMAD4 in papillary RCC (E). IHC staining of breast cancer tissue as positive (F) and negative (G) controls. (A–C) are presented with a magnification of 400×, (D–G) are presented with a magnification of 200×).