Figure 1.

CONSORT flow diagram showing progress through the stages of the study, including flow of participants, withdrawals, and inclusion in analyses. A total of 212 individuals were screened by phone or e-mail. Of these 78 children did not meet the study criteria and 28 declined participation. The remaining 106 children potentially met the study criteria and were invited to undergo physical screening. Ten children were excluded and 13 who qualified declined to participate. The remaining 83 children were stratified by age, sex, baseline hand function and CST connectivity pattern, and randomized to receive either CIMT or HABIT. One child in the HABIT group dropped out before starting treatment, and 41 children in each group completed the intended treatments. We were unable to complete TMS or DTI on 3 participants due to exceedingly high thresholds or safety concerns, so only data of the 79 participants with CST determination were included (39 for CIMT, 40 for HABIT).