Table 1.
Patient origin (trial) and baseline characteristics of split datasets
| Training cohort (%) |
Test cohort (%) |
|||
|---|---|---|---|---|
| all-P (n = 2,021) | rand-P (n = 863) | all-P (n = 2,020) | rand-P (n = 862) | |
| Trial | ||||
| CENTRIC (randomized) | 264 (13.1) | 264 (30.6) | 262 (13.0) | 262 (30.4) |
| CENTRIC (screened) | 1,058 (52.4) | NA | 1,058 (52.4) | NA |
| CORE (randomized) | 132 (6.5) | 132 (15.3) | 133 (6.6) | 133 (15.4) |
| CORE (screened) | 100 (4.9) | NA | 100 (5.0) | NA |
| AVAGlio | 170 (8.4) | 170 (19.7) | 170 (8.4) | 170 (19.7) |
| RTOG 0825 | 297 (14.7) | 297 (34.4) | 297 (14.7) | 297 (34.5) |
| Baseline characteristics | ||||
| Performance status (randomized patients only) | ||||
| PS = 0 | NA | 516 (59.8) | NA | 514 (59.6) |
| PS ≥ 1 | NA | 347 (40.2) | NA | 345 (40.0) |
| Missing | NA | 0(0) | NA | 3 (0.4) |
| Extent of resection (randomized patients only) | ||||
| Complete resection | NA | 454 (52.6) | NA | 453 (52.6) |
| Partial resection | NA | 394 (45.7) | NA | 392 (45.5) |
| Biopsy only | NA | 6 (0.7) | NA | 7 (0.8) |
| Other | NA | 8 (0.9) | NA | 8 (0.9) |
| Missing | NA | 1 (0.1) | NA | 2 (0.2) |
| Age in years (randomized patients only) | ||||
| Median (Q1, Q3) | NA | 57 (50, 63) | NA | 57.5 (50, 64) |
| Corrected log2 MGMT ratio | ||||
| Median (Q1, Q3) | −0.58 (−2.00, 3.24) | 0.63 (−1.97, 4.77) | −0.58 (−1.96, 3.54). | 1.06 (−1.79, 4.94) |