Table 2.
Outcome by MGMT promoter methylation status in the rand-P training and test cohorts
| Methylation status | N (%) | Observed events | Median survival (months) | HR (95% CI) | P | Adj. HR (95% CI)a | Padj |
|---|---|---|---|---|---|---|---|
| Training cohort | |||||||
| Truly unmethylated | 378 (43.8) | 302 | 14.0 (13.1–14.7) | 1.00 | – | 1.00 | – |
| Gray zone | 82 (9.5) | 50 | 18.5 (16.2–25.0) | 0.58 (0.43–0.78) | <0.001 | 0.64 (0.47–0.87) | <0.01 |
| Methylated | 403 (46.7) | 203 | 26.5 (25.1–30.2) | 0.35 (0.27–0.45) | <0.0001 | 0.32 (0.25–0.42) | <0.0001 |
| Test cohort | |||||||
| Truly unmethylated | 375 (43.5) | 299 | 13.6 (12.9–14.7) | 1.00 | 1.00 | ||
| Gray zone | 70 (8.1) | 46 | 16.5 (13.8–20.6) | 0.70 (0.51–0.96) | 0.03 | 0.71 (0.52–0.97) | 0.03 |
| Methylated | 417 (48.4) | 219 | 25.6 (23.2–28.4) | 0.38 (0.29–0.49) | <0.0001 | 0.36 (0.28–0.46) | <0.0001 |
a
Adjusted for age, ECOG performance status, and extent of resection.