a Concentration response curves in three representative NCI60 panel cell lines after compound exposure for 2 days (blue), 3 days (red), 7 days (yellow) or 11 days (green) for the PARP inhibitors rucaparib, niraparib, olaparib, talazoparib, and veliparib. b Concentration response curves in three representative NCI60 panel cell lines after compound exposure for 2 days (blue), 3 days (red), 7 days (yellow) or 11 days (green) for the SMO inhibitors saridegib and LEQ-506 and the IAP inhibitors birinapant and LCL-161