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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Semin Nephrol. 2020 Nov;40(6):564–573. doi: 10.1016/j.semnephrol.2020.12.003

Figure 1: Uric acid biology.

Figure 1:

A. History of primate order evolution over 80 million years and subdivision into families. Progressive rise in uric acid levels parallels the loss of uricase activity from prosimians to humans. B. The rise in serum uric acid concentration is compared to urine uric acid-to-creatinine concentration; fractional excretion of urate was only available in very few species.