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ATRi and PARPi combination caused increased apoptosis in IDH1-mutant cells. HCT116 (WT and IDH1-R132H/+) cells were treated with olaparib (1 μM), AZD6738 (500 nM) or both for 24 h (left panel) or 48 h (right panel). Lysates were harvested after 24 and 48 h. Cleaved caspase-3 and cleaved PARP was evaluated by western blot analysis.
