Structures of TriM variants and associated antimicrobial activity against Gram-negative bacteria.

Compound no.	Analogue	Variable residues				MIC (μg mL−1)
		5	9	11	12	K. pneumoniae AH-3 (Col-R)	S. marcescens MTCC 97
92	M1	d-Trp	l-Ile	l-Ile	d-aIle	4	8
93	M2	d-Trp	l-Ile	l-Val	d-Val	8	>16
94	M5	d-Phe	l-Ile	l-Ile	d-Val	16	8
95	M6	d-Trp	l-Ile	l-Ile	d-Val	4	16
96	M7	d-Trp	l-Val	l-Ile	d-aIle	8	8
97	M8	d-Phe	l-Ile	l-Ile	d-aIle	8	16
98	M11a	ND	l-Phe	l-Ile	d-aIle	1	4

^aResidues 1–7 could not be conclusively determined.