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. 2021 May 14;9:e11422. doi: 10.7717/peerj.11422

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©2021 Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Volcano plot of differentially expressed genes. Red nodes represent the significantly up-regulated genes with logFC > 2 and p < 0.05. Green nodes represent the significantly down-regulated genes with logFC < −2 and p < 0.05. (B) Heatmap of enriched terms across DEGs in Metascape analysis. (C) Enrichment plot of ECM receptor interaction pathway from GSEA. (D) The Venn diagram of the common genes, which is obtained by intersecting the core genes of the ECM pathway with DEGs.