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. 2020 Nov 22;9(2):154–165. doi: 10.1093/gastro/goaa085

Figure 1.

Figure 1.

Sodium butyrate alleviates LPS-induced liver injury and inflammation. (A) H&E staining, immunohistochemical staining for MPO and TUNEL staining of liver tissue in C57BL/6 mice treated with SB, SB + LPS, LPS, and the vehicle group (magnification, ×200). (B) Histology score of hemorrhage, MPO index, and apoptosis index was calculated from TUNEL staining in C57BL/6 mice treated with SB, SB + LPS, LPS, and the vehicle group. (C) Serum levels of ALT and AST were detected using ELISA kits in female C57BL/6 mice treated with normal saline, SB, LPS, and SB + LPS. (D) RT-PCR was used to determine relative mRNA levels of TNF-α, IL-6, and IL-1β in liver tissues.*P < 0.05 vs vehicle group; #P < 0.05 vs LPS group. Values are expressed as mean ± SD (n = 10 in each group). MPO, myeloperoxidase; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; SB, sodium butyrate; LPS, lipopolysaccharide; ALT, alanine aminotransferase; AST, aspartate transaminase.