Fig. 2. (a and b) Superimposition of (a) mTOR–1 and mTOR–2 complexes and (b) mTOR–3 and mTOR–4 complexes. mTOR, grey; 1, green; 2, brown; 3, yellow; 4, cyan. The distances between the 2-amino group and Glu2190/Asp2195 are depicted as dashed black lines. Distances values are coloured as the inhibitors. (c and d) Docking of compound 11 (magenta) to (a) mTOR (grey) starting from PDB 4JT6,²² and (b) PI3Kα (wheat) starting from PDB 6OAC.²¹ No steric clashes are present with Asp2357 and Lys2187 in mTOR (c). Steric clashes with Asp933 and Lys802 in PI3Kα are shown (d).