Fig. 3. (a) Efflux ratio (ER) in MDCK cells with and without hMDR1 grown on TransWell filters. An ER of 1 is indicative of the compound not being a hMDR1 substrate. (b) Apparent permeability (Papp) from apical to basolateral site in MDCK-hMDR1cMDR1ko cells. Numerical values are reported in Tables S1 and S2.† *p < 0.05, unpaired t-test, GraphPad Prism 8.0.2.
