Skip to main content
. Author manuscript; available in PMC: 2021 May 17.
Published in final edited form as: Cancer Res. 2019 Sep 26;79(24):6227–6237. doi: 10.1158/0008-5472.CAN-19-0179

Figure 5: Integrative analysis of radiobiological model with transcriptomic data and prediction of radioresponse under hypoxia.

Figure 5:

(A) Hypothetical illustration of cancer cell surviving fraction according to dose and oxygen partial pressure, as modeled using RadioGx. Solid curves are modeled using Equation (3) (Methods). The computed AUC values are 2.41, 2.71, 2.97 for normoxia (160 mmHg), hypoxic condition with 10 mmHg, and hypoxic condition with 5 mmHg, respectively. (B) Changes in AUC by tissue type (with minimum of 15 cell lines within RadioGx) under normoxic (160 mmHg) or hypoxic (5 mmHg) conditions, ordered according to median AUC under normoxia. (C) The difference in ranks are shown between the strength of univariate association of each gene with AUC under normoxic (160 mmHg) vs. hypoxic (5 mm Hg) conditions across cancer cell lines within RadioGx.