Table 3.

Factors associated with the presence of clinically relevant drug–drug interactions (type D and/or X) adjusted for age and sex.

	OR	95% CI	p
Number of drugs
5–6 drugs	Reference
7–9 drugs	2.83	1.89–4.25	<0.001
≥10 drugs	11.86	6.92–20.33	<0.001
Anxiety/depression	1.98	1.31–2.98	<0.001
Arterial hypertension	0.62	0.41–0.94	0.02
Diabetes	0.57	0.40–0.82	0.003
Ischaemic heart disease	0.43	0.25–0.74	0.002

Pseudo-R²: 0.1353; Akaike’s information criterion: 728.87; Bayesian information criterion: 768.34.

Type D interaction: consider therapy modification; Type X interaction: avoid combination.