Fig. 1. Description of the extended immuno-epidemiological model with one- and two-dose vaccination regimes.

Based on (13). (A) Model flow chart depicting transitions between immune classes (see main text and materials and methods for a full description of the immune classes and parameters). (B) Diagram of the interdose period $\left(\frac{1}{\mathrm{\omega }}\right)$ between the first and second vaccine doses and its relationship to the rate of administration of the first vaccine dose ν. The maximum achievable rate is ν₀ for a fully one-dose strategy, and ν is assumed to decrease exponentially to its lowest value ν₀/2 when a fully two-dose strategy with interdose period corresponding to the clinical recommendation (L_opt) is used. (C) Representative schematic of societal composition of various immune classes for the SIR(S) model with no vaccination (left), the extended model with a short interdose period (middle), and the extended model with a long interdose period (right).