TABLE 1.

Characteristics of procoagulant platelets during apoptosis and necrosis (summarized from Jackson et al ¹⁸ )

Characteristics	Apoptosis	Necrosis	Procoagulant platelets
Stimulus	Ratio of Bclxl to Bax/Bak	Cyclophilin D	Activation of GP VI receptor and/or protease‐activated receptors (e.g., thrombin, collagen, collagen‐related peptide)
Ca+ Dependence	Independent of Ca+	Dependent on Ca+	Dependent on Ca+
Morphology	Cell shrinkage and apoptotic body formation	Cell swelling	Cell swelling and ballooning
Membrane integrity	Loss in the late stage	Loss in the early stage	Loss of membrane integrity
Mitochondrial transmembrane potential (ΔΨm)	Loss in the late stage	Loss in the early stage	Loss of ΔΨm
PS exposure	Exposed in the late stage	Exposed in the early stage	Exposed
Formation of MPTP	No	Yes	Yes
Method of inhibition	Bax/Bak knockout	Cyclophilin D knockout	Cyclophilin D knockout

Abbreviations: GP VI, glycoprotein VI; mPTP, mitochondrial permeability transition pore; PS, phosphatidylserine.