TABLE 3.

Kaplan‐Meier curve and Cox regression of the clinical characteristics and the four inflammatory ratios in patients with metastatic CMA.

Parameter		P‐value	Crude HR(95%CI)	Adjusted HR(95%CI)
Gender (male)		0.128	1.660(0.864–3.189)	1.195(0.544–2.629)
Age (>60 year)		0.070	2.116(0.941–4.761)	2.020(0.898–4.542)
Smoking (yes)		0.306	1.651(0.632–4.309)	2.085(0.377–11.528)
Drinking (yes)		0.473	1.549(0.469–5.113)	0.552(0.119–2.567)
Diabetes (yes)		0.304	1.729(0.608–4.917)	1.375(0.424–4.460)
Hypertension (yes)		0.827	1.173(0.279–4.943)	0.542(0.108–2.733)
T stage (T3‐4)		0.920	3.211(0.623–6.214)	3.655(0.320–6.230)
LN status (N1‐2)		0.095	1.949(0.891–4.267)	2.521(0.983–5.871)
Differentiation (G1‐2)		0.912	1.053(0.425–2.607)	1.021(0.410–2.599)
Cancer bulk (>5 cm)		0.833	1.095(0.470–2.553)	1.015(0.479–2.563)
Primary location (right)		0.079	0.551(0.283–1.071)	0.441(0.216–0.901)
Palliative operation (yes)		0.300	0.692(0.345–1.388)	0.666(0.324–1.370)
Radio‐chemotherapy (yes)		0.227	0.557(0.215–1.441)	0.551(0.209–1.456)
Targeted therapy (yes)		0.906	0.954(0.434–2.095)	1.462(0.535–3.998)
CEA (>5 ng/mL)		0.135	1.694(0.849–3.383)	1.545(0.764–3.126)
CA19‐9 (>37 U/mL)		<0.001	4.196(1.896–9.286)	3.855(1.746–8.509)
NAR (score=1)		0.529	1.272(0.600–2.696)	1.902(0.885–4.088)
NPAR (score=1)		0.133	1.678(0.853–3.300)	2.405(1.195–4.842)
AFR (score=1)		0.156	0.585(0.279–1.227)	0.863(0.283–2.364)
FPR (score=1)		0.007	2.521(1.282–4.960)	2.364(1.203–4.645)

LN: lymph node; NAR: neutrophil‐to‐albumin ×100; NPAR: neutrophil‐ to‐pre‐albumin ratio×1000; AFR: albumin‐to‐fibrinogen ratio; FPR: fibrinogen‐to ‐pre‐albumin ratio ×1000; p‐value: the value of Kaplan‐Meier curve with log‐rank test; HR: hazard ratio; CI: confidence interval; right location means the caecum, ascending colon and transverse colon, the others were considered as left tumor location; multivariable Cox regression is adjusted by gender, age, tobacco, alcohol, diabetes, hypertension, treatment, T and N status, differentiation, cancer size, primary location.