Study	Best evidence?	Rationale
Axelrod 2005	Yes	Observational study and met all applicable POST‐I criteria. Addresses gap in evidence by examining the long‐term effects (nearly 40 years) of fludrocortisone in people with familial dysautonomia.
Axelrod 1997	No	Observational study but did not report baseline differences between groups and didn't account for it in analysis (“No” to POST‐I item #5)
Campbell 1975	Yes	RCT
Campbell 1976	No	Observational study but did not use repeated measures at baseline and follow‐up (“No” to POST‐I item #6) and could not rule out that effect was due to confounding (“No” to POST‐I item #7)
Chobanian 1979	No	Observational study but was not particularly careful at measuring outcomes (“No” to POST‐I item #6) and could not rule out that effect was due to confounding (“No” to POST‐I item #7)
Kochar 1978	No	Observational study but was not particularly careful at measuring outcomes (“No” to POST‐I item #6) and could not rule out that effect was due to confounding (“No” to POST‐I item #7)
Matsubara 1990	No	Observational study but was not particularly careful at measuring outcomes (“No” to POST‐I item #6) and could not rule out that effect was due to confounding (“No” to POST‐I item #7)
Pathak 2005a	No	Observational study but did not report baseline differences between groups and didn't account for it in analysis (“No” to POST‐I item #5)
Pathak 2005b	No	Observational study but did not report baseline differences between groups and didn't account for it in analysis (“No” to POST‐I item #5)
Schatz 1976	No	Observational study but was not particularly careful at measuring outcomes (“No” to POST‐I item #6) and could not rule out that effect was due to confounding (“No” to POST‐I item #7)
Schoffer 2007	Yes	RCT
Schreglmann 2017	Yes	RCT
Ten Harkel 1992	Yes	Observational study and met all applicable POST‐I criteria. Addresses gap in evidence by examining long‐term (14 months) effects and harms of fludrocortisone in people with orthostatic hypotension from a variety of underlying conditions.