Campbell 1975.

Study characteristics
Methods	Cross‐over RCT
Participants	Setting: Diabetic and Dietetic Department, University Department of Medicine, The Royal Infirmary, Edinburgh Number of participants: 6 Unit of randomization: individual Age (mean): 50 Diagnostic criteria of orthostatic hypotension: symptomatic postural hypotension with a fall of systolic BP of 30 mmHg or greater immediately on changing from the lying to standing position Severity of OH: see “diagnostic criteria of orthostatic hypotension” Severity of underlying illness: severe diabetic neuropathy Inclusion/exclusion criteria: see “diagnostic criteria of orthostatic hypotension”
Interventions	Intervention: 0.1 mg of fludrocortisone twice a day for 3 weeks Comparator: placebo twice a day for 3 weeks
Outcomes	Time points reported: baseline, 3 weeks Primary outcome: mean systolic and diastolic BP in lying and tilted position at 1‐min increments Secondary outcomes: orthostatic symptoms
Notes	Conflicts of interest not reported. Fludrocortisone and placebo tablets were supplied by ER Squibb and Son, Ltd
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details provided
Allocation concealment (selection bias)	Unclear risk	No details provided
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Low for BP; unclear for symptoms
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Low for BP; unclear for symptoms
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Low for BP; unclear for symptoms, 16% attrition while taking active drug for reason of "defaulted"
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Unclear risk	First period data not available. No assessment for period effect