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. 2021 May 13;15:2013–2024. doi: 10.2147/DDDT.S289473

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© 2021 Nan et al.

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EGCG diminishes Tau hyperphosphorylation and BACE1 expression in hippocampus of AD rats. Sham-operated rats were used as controls, whereas AD rats were untreated or treated with 100 mg/kg EGCG, 250 mg/kg EGCG and 625 mg/kg EGCG. (A) Immunohistochemistry determination of Tau phosphorylation in rat hippocampus (× 400); (B) Western blot analysis of BACE1 expression and Tau hyperphosphorylation. *p < 0.05 vs sham-operated rats, ^#p < 0.05 vs AD rats. Data among multiple groups were checked by one-way ANOVA with Tukey’s post hoc test, n = 15.