Figure 5.
BC downregulated module is associated with placenta size and candidate imprinted genes. (A) Summary expression of the BC downregulated module was significantly associated with placenta size controlling for Theiler stage and sex (P < 0.001, ANOVA, see Supplementary Table S3). (B) This module was enriched for highly connected, candidate imprinted genes (µimprinted=0.8489 ± 0.015; µnon imprinted=0.6370 ± 0.008; Welch’s two-sided t-test, t49.315 = 12.255, P < 0.0001; total genes, N = 432; imprinted genes, N = 33). Data points rendered only for imprinted genes. (C) The top 500 pairwise connections within this network largely involved the top 5% most connected genes, with interactions involving hub genes denoted by a thicker line and a solid black circumference notation at the interaction partner. Interactions involving a candidate imprinted gene are indicated in blue.