Table 1.
Hub genes in the downregulated, placenta-associated BC module
| Gene name | No. of interactions in top 500 | Module membership | Imprinting status | Function (UniProtKB) | Clotting/ angiogenesis | Immune | Growth and development | References |
|---|---|---|---|---|---|---|---|---|
| Plxdc2 | 32 | 0.9259 | Candidate | Cell surface signaling | Maybe | — | Yes | Cheng et al. 2014 |
| Procr | 28 | 0.9451 | Candidate | Cell surface signaling, blood coagulation | Yes | Yes | — | Sood et al. 2006; Bouwens et al. 2013 |
| Scara5 | 23 | 0.9218 | Candidate | Iron transport, blood coagulation | Yes | — | Yes | Li et al. 2009 |
| Cd68 | 20 | 0.9133 | Candidate | Immune function | — | Yes | — | Chistiakov et al. 2017 |
| Wnt4 | 20 | 0.9451 | Candidate | Developmental signaling | — | — | Yes | Sonderegger et al. 2010; Knöefler and Pollheimer 2013 |
| Ppard | 19 | 0.9181 | — | Transcription factor; steroid hormone receptor | — | — | Yes | Schmidt et al. 1992 |
| Adm | 18 | 0.9515 | — | Immune function | Yes | Yes | — | Li et al. 2013 |
| Boc | 18 | 0.9217 | — | Cell–cell adhesion, tissue differentiation | — | — | Yes | Zakaria et al. 2019 |
| Igsf11 | 17 | 0.8696 | — | Cell–cell adhesion, cell growth, neurogenesis | — | — | Yes | Jang et al. 2016 |
| Erv3 | 17 | 0.9463 | Candidate | Tissue identity and immunomodulation | — | Yes | Yes | Mangeney et al. 2007 |
| Tbc1d2b | 16 | 0.8934 | — | Protein modification and transport | — | — | Yes | Manshouri et al. 2019 |
| Olfml3 | 15 | 0.8884 | Candidate | Developmental signaling | Yes | — | — | Miljkovic-Licina et al. 2012 |
| Lmcd1 | 13 | 0.9115 | — | Transcription factor | — | — | Yes | Ferreira et al. 2019 |
| Fn3krp | 12 | 0.8801 | — | Protein modification/glycation | Maybe | Maybe | Yes | Karabag et al. 2007 |
| Numbl | 11 | 0.879 | — | Cell–cell adhesion, neurogenesis | — | — | Yes | Wilson et al. 2007 |
| Ipmk | 11 | 0.8049 | — | Lipid metabolism | — | — | Yes | Malabanan and Blind 2016 |
| F13a1 | 10 | 0.888 | — | Metal binding, blood coagulation | Yes | — | — | Muszbek et al. 2011 |
| Pdpn | 10 | 0.8987 | — | Cell–cell adhesion, developmental signaling | — | Yes | — | Astarita et al. 2012 |
| Larp6 | 10 | 0.824 | — | Collagen biosynthesis, fibrosis | — | — | Yes | Stefanovic et al. 2019 |
| Gypc | 10 | 0.8474 | — | Cell membrane stability, red blood cells | Yes | — | — | Wilder et al. 2009 |
| Fut4 | 10 | 0.8666 | — | Cell–cell adhesion, immune function | Maybe | Yes | — | Wang et al. 2013 |
The top 5% most connected genes in the downregulated module, with connection defined as the number of times the gene was included in the top 500 strongest pairwise correlations in gene expression between genes in the module. Gene imprinting status (Brekke et al. 2016) and functions are indicated.