Table 2.
Summary of the SDL growth phenotypes of mutants that exhibit SDL with GALCSE4 and combined with hhf1Δ or hhf2Δ
| Protein function | Relevant strain genotype | Growth with GALCSE4 |
|---|---|---|
| WT | ++ | |
| Histone H4 | hhf1Δ | +++ |
| hhf2Δ | +++ | |
| Histone H2A | hta1Δ | ++ |
| hta2Δ | ++ | |
| Histone H3 | hht1Δ | ++ |
| hht2Δ | ++ | |
| E3 Ubiquitin Ligase | psh1Δ | — |
| psh1Δ hhf1Δ | +++ | |
| psh1Δ hhf2Δ | +++ | |
| psh1Δ hhf1Δ + HHF1 | — | |
| psh1Δ hhf2Δ + HHF2 | — | |
| psh1Δ hta1Δ | — | |
| psh1Δ hta2Δ | — | |
| psh1Δ hht1Δ | — | |
| psh1Δ hht2Δ | — | |
| SUMO-Targeted Ubiquitin Ligase | slx5Δ | — |
| slx5Δ hhf1Δ | +++ | |
| slx5Δ hhf2Δ | +++ | |
| Ubiquitin Binding | doa1Δ | — |
| doa1Δ hhf1Δ | +++ | |
| doa1Δ hhf2Δ | +++ | |
| HIR Nucleosome Binding Complex | hir2Δ | — |
| hir2Δ hhf1Δ | ++ | |
| hir2Δ hhf2Δ | — | |
| F-box of the SCF Complex | cdc4-1 | — |
| cdc4-1 hhf1Δ | +++ | |
| cdc4-1 hhf2Δ | +++ | |
| Dbf4-Dependent Kinase | cdc7-4 | — |
| cdc7-4 hhf1Δ | ++ | |
| cdc7-4 hhf2Δ | ++ |
Shown is the protein function, relevant strain genotype, and growth with GALCSE4. Wild type growth is indicated as ++; SDL as — and extent of suppression (++ or +++).