TABLE 1.

Results of the Unsupervised Clustering of Samples Based on the Explanatory Latent Factors Associated with the Traits.

Trait	LFa	Dominantomic layer	Correlation Between Cluster Membership and Clinical Rraits	R2	P	Optimal Clustering	Enrichment of Traits in Clustersb
Disease location	LF12	CD14	Yes	0.42	0.0164	k = 2	No
Disease behavior	LF11	CD14	Yes	−0.29	0.0965	k = 5	No
Disease behavior	LF11	CD4	Yes	−0.29	0.0965	k = 5	No
Perianal disease	LF9	CD14	Yes	0.45	0.00834	k = 3	Yes
Number of anti-TNF agents exposed to	LF5	CD14	Yes	0.437	0.0109	k = 2	No
Exposure to Vedolizumab	LF3	CD14	Yes	0.563	0.0006	k = 2	Yes
Exposure to Vedolizumab	LF5	CD14	Yes	0.46	0.007	k = 2	Yes
Smoking	LF9	CD14	Yes	−0.3255	0.6453	k = 2	No

^aEnrichment was deemed as significant for those overrepresentation events with an adjusted P value of ≤ 0.1.

^bLFs associated with gender were discarded to exclude sex specific signals.