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. 2021 May 10;48(1):124. doi: 10.3892/ijmm.2021.4957

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Neferine inhibits the growth of head and neck squamous cell carcinoma by inducing apoptosis and autophagy in vivo. (A) Representative images of xenografts constructed by CAL27 cells, treated with vehicle or neferine. (B) The line chart depicts the growth rate of tumors treated with neferine compared to the control. (C) H&E staining and immunohistochemical staining of Ki67, cleaved caspase-3, cleaved PARP1, LC3, and p62 in xenograft tumor tissues treated with neferine or vehicle. ^**P<0.01.