Table 1. Statistics on the gene-regulatory activities from the parent and designed libraries.

Library data is grouped based on aptamer, and the distributions are analyzed to determine the mean gene-regulatory activity value and fraction of sequences in the library that fell below a threshold gene-regulatory activity value (set as log10(GFP/mCh) = 0).

	Folinic acid	Theophylline	Tetracycline	Chloramphenicol	Neomycin
Mean log10(GFP/mCh) value for parent library	0.624	0.553	0.443	0.485	0.726
Mean log10(GFP/mCh) value for designed library	–0.361	0.312	0.296	0.383	0.641
Fraction below log10(GFP/mCh) = 0.0 for parent library	0.027	0.024	0.012	0.001	0.001
Fraction below log10(GFP/mCh) = 0.0 for designed library	0.772	0.151	0.076	0.006	0.0
Result of rank-sum test (p-value)	1.2 × 10–91	1.0 × 10–34	8.0 × 10–36	1.6 × 10–23	4.8 × 10–42