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. 2021 May 8;2021:9944132. doi: 10.1155/2021/9944132

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Copyright © 2021 Fanguo Kong et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

NOLC1 overexpression promotes oncogenesis and progression of ESCC via activating PI3K/AKT pathway. (a) The activation of PI3K/AKT pathway in Eca109 and TE-13 cells. (b) PI3K inhibitor LY294002 blocked cell proliferation mediated by NOLC1 overexpression vs. oe-NOLC1 group, ∗p < 0.05. (c) LY294002 impeded apoptosis rate caused by NOLC1 overexpression. (d) LY294002 abrogated invasion ability caused by NOLC1 overexpression. (e) LY294002 abolished migration ability induced by NOLC1 overexpression. (f) LY294002 reversed the expression of cyclin B1 and cleaved-caspase-3 induced by NOLC1 overexpression.