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. 2021 Jan 18;58(6):2523–2541. doi: 10.1007/s12035-020-02276-8

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021, corrected publication 2021

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Fig. 4 — More Sig-1Rs are seen at the nuclear envelope after SNI. (a) Confocal images show clear localization of Sig-1R (red) near DNA maker 4’-6-diamidino-2-phenylindole (DAPI; blue) in respective places in the sham or SNI rat DRGs. (b) Summary data on neurons which demonstrate colocalization of Sig-1R and DAPI in skin sham or SNI DRG. (c, d) Traces of Sig-1R (red) and DAPI (blue) in the two cells shown in (A) simply to show that the cell in (D) showed a presumed nucleopasmic reticulum-associated ‘sipke’ of Sig-1R after SNI. Data are shown as means ± SEM. The means were calculated from the ratio of “Sig-1R and DAPI colocalized neurons” to total of neurons counted in each animal; number in bars represents animal number. Note: in the 3 sham animals, 37 of 172 neurons show observed colocalization; in SNI animals, 55 of 151 neurons show as such. Two experimenters made the decision, on single blind basis, on the colocalization of Sig-1R and DAPI by eyeballing images like those in (A). The image provider then calculated the results obtained from the two persons. Fisher’s exact test was used to test the difference; **P < 0.05