Fig. 3.

Renal fibrosis and injury correlate with serum CN-1 overexpression in DN with macroalbuminuria. IHC staining of fibrosis indexes in three groups, including FN, COL-IV, COL-I (a). Quantitative results of FN (b), COL-IV (c), COL-I (d) in IHC staining. Correlation of serum CN-1 expression with various parameters, including FN (e), COL-IV (f), COL-I (g). IHC staining of oxidative stress indexes KIM-1 (h) in three groups. Quantitative results of KIM-1 (i) in IHC staining. Correlation of serum CN-1 expression with KIM-1 (j). Representative microscopic images are shown (× 200 magnification). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001