Table 1.
Baseline demographic, clinical, and laboratory data of patients
| MCD (n = 14) | DN | F/χ2 | p value | ||
|---|---|---|---|---|---|
| Microalbuminuria (n = 11) | Macroalbuminuria (n = 26) | ||||
| Age (years) | 40.86 ± 13.34 | 52.18 ± 5.81 | 50.08 ± 7.17 | 6.213a,b | 0.004 |
| Sex (male/female)* | 8/6 | 7/4 | 19/7 | 1.098 | 0.578 |
| BMI (kg/m2) | 24.69 ± 2.35 | 24.63 ± 2.00 | 25.52 ± 3.07 | 0.646 | 0.528 |
| SBP (mmHg) | 120.93 ± 9.75 | 134.09 ± 18.10 | 141.62 ± 15.14 | 9.124a,b | 0.000 |
| DBP (mmHg) | 79.36 ± 6.78 | 83.36 ± 13.60 | 84.62 ± 10.67 | 1.154 | 0.324 |
| FBG (mmol/L) | 4.94 ± 0.47 | 7.68 ± 3.16 | 7.88 ± 3.69 | 4.593a,b | 0.015 |
| HbA1c (%) | 4.92 ± 0.35 | 7.87 ± 1.54 | 7.46 ± 1.63 | 19.187a,b | 0.000 |
| Alb (g/L) | 20.85 ± 5.55 | 41.4 ± 2.36 | 34.76 ± 7.44 | 37.888a,b,c | 0.000 |
| BUN (mmol/L) | 5.00 ± 1.63 | 6.5 ± 2.17 | 8.89 ± 3.5 | 9.107b | 0.000 |
| UA (μmol/L) | 382.07 ± 134.07 | 372.64 ± 119.03 | 399.92 ± 72.42 | 0.318 | 0.729 |
| SCr (μmol/L) | 71.09 ± 24.54 | 76.72 ± 34.23 | 125.51 ± 53.67 | 9.065b | 0.000 |
| eGFR (mL/min/1.73m2) | 110.14 ± 27.36 | 99.18 ± 25.76 | 68.00 ± 30.38 | 11.250a,b | 0.000 |
| TC (mmol/L) | 8.36 ± 2.04 | 3.78 ± 0.38 | 5.26 ± 1.5 | 30.948a,b,c | 0.000 |
| TG (mmol/L) | 1.84 ± 0.58 | 2.54 ± 0.80 | 1.8 ± 0.96 | 3.218 | 0.049 |
| CRP (mg/L) | 0.89 ± 0.69 | 1.48 ± 1.21 | 1.45 ± 0.82 | 2.093 | 0.134 |
| U-AER (mg/24 h) | 5490.71 ± 2872.62 | 164.21 ± 103.18 | 2534.31 ± 2215.21 | 18.731a,b,c | 0.000 |
| 24 h-U-PRO/CRE | 6.2 ± 3.49 | 0.41 ± 0.3 | 4.99 ± 4.00 | 9.817a,b | 0.000 |
Data are expressed as mean ± SD, or number
BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, HbA1c glycosylated hemoglobin, Alb albumin, BUN blood urea nitrogen, UA uric acid, SCr serum creatinine, eGFR estimated glomerular filtration rate, TC total cholesterol, TG triglyceride, CRP C-reactive protein, U-AER Urinary albumin excretion rate, 24 h-U-PRO/CRE 24-h urinary protein creatinine ratio
*Chi-square inspection
ap < 0.05 (post hoc), DN with microalbuminuria vs. MCD
bp < 0.05 (post hoc), DN with macroalbuminuria vs. MCD
cp < 0.05 (post hoc), DN with microalbuminuria vs. DN with macroalbuminuria