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. 2021 Feb 14;58(6):2974–2989. doi: 10.1007/s12035-021-02319-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — HIV-exosomes contain HIV-1 Tat protein and viral Tat protein reduce p-DRP1, and p-eNOS expression in primary HBMVECs. a HIV-1 Tat protein in U1 Exo, U937 Exo, and U1 cell lysate was detected (20 μg protein) by western blotting. Recombinant HIV-Tat protein (50 ng) was used as positive control. b Representative western blot of p-eNOS and total eNOS in cells exposed to U1 Exo. c Quantitative analysis of p-eNOS and total eNOS. d Representative western blot, and e quantitative analysis of p-DRP1 and total DRP1 in cells exposed to recombinant HIV-Tat protein. f Representative western blot, and g quantitative analysis of p-eNOS and total eNOS in cells exposed to recombinant HIV-Tat protein. Error bars show mean ± SD, n = 3 independent experiments, and significant changes are presented as p values (*p < 0.05)