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. 2021 May 17;11:10431. doi: 10.1038/s41598-021-89770-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Timeline Kinetics of Serum Biomarkers in Patients with Autoimmune Disease According to the Neutralizing Antibody Status After Planned Primary 17DD-YF Vaccination. Panoramic timeline kinetics of serum chemokines (CXCL8, CCL11, CCL3, CCL4, CCL2, CCL5, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-15, IL-17), regulatory cytokines (IL-1Ra, IL-4, IL-5, IL-9, IL-10, IL-13), and growth factors (FGF-basic, PDGF, VEGF, G-CSF, GM-CSF, IL-2 and IL-7) in serum samples from Autoimmune Disease patients, categorized according to the PRNT status after primary 17DD-YF vaccination: AID/PRNT(−) (black filled inverted triangle, n = 32) and AID/PRNT(+) (white filled inverted triangle, n = 108). Measurements were carried out using the Luminex platform, according to manufacturer’s instructions as provided in Material and Methods. The results are expressed as median baseline fold changes ± variation at each time point along the kinetic follow-up (D3–4, D5–6, D7 and D14–28) according to the paired sample collected at D0. Data analysis was performed considering the baseline fold value = 1.0 as the reference for decrease (< 1.0) or increase (> 1.0) in biomarker levels along the kinetic timeline.