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. 2021 May 17;11:10431. doi: 10.1038/s41598-021-89770-8

Figure 3.

Figure 3

Baseline Profile of Serum Biomarkers in Patients with Autoimmune Disease According to the Neutralizing Antibody Status After Planned Primary 17DD-YF Vaccination. Baseline levels of serum chemokines (CXCL8, CCL11, CCL3, CCL4, CCL2, CCL5, CXCL10), pro-inflammatory cytokines (IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-15, IL-17), regulatory cytokines (IL-1Ra, IL-4, IL-5, IL-9, IL-10, IL-13), and growth factors (FGF-basic, PDGF, VEGF, G-CSF, GM-CSF, IL-2 and IL-7) in serum samples from Autoimmune Disease patients, categorized according to the PRNT status after primary 17DD-YF vaccination: AID/PRNT(−) (black filled square, n = 32) and AID/PRNT(+) (white filled square, n = 108). Measurements were carried out using the Luminex platform, according to manufacturer’s instructions as provided in Material and Methods. The results are expressed as median levels (pg/mL) at baseline (D0) on boxplot charts. Comparative analysis between AID/PRNT(−) and AID/PRNT(+) was carried out by Mann–Whitney test and significant differences at p < 0.05 underscored by connecting lines and highlight with gray background. The exact p values are provided in the figure.