Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 17;11:10431. doi: 10.1038/s41598-021-89770-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Serum Biomarker Signatures in Patients with Autoimmune Disease After Planned Primary 17DD-YF Vaccination. (A) Kinetics of serum biomarker signatures at distinct time points after primary 17DD-YF vaccination of Autoimmune Disease patients (AID, n = 140, D3–4 = light grey filled square, D5–6 = grey filled square, D7 = dark grey filled square and D14–28 = black filled circle) and Healthy Controls (HC, n = 21, D3–4 = light grey filled circle, D5–6 = grey filled circle, D7 = dark grey filled circle and D14–28 = black filled circle). The results are expressed as the proportion of subjects with increased biomarker levels (baseline fold change values > 1). Data analysis was carried out considering the 50th percentile as the reference to identify the set of biomarkers with high proportion of subjects with levels above the global median cut-off along the kinetic timeline. Those biomarkers with proportion of subjects with levels above the global median cut-off were highlighted with gray scale rectangles. (B) Heatmaps were constructed considering the baseline fold change values at each time point along the kinetic follow-up (D3–4, D5–6, D7 and D14–28). This approach was employed to draw the overall change in the serum biomarkers profile after primary 17DD-YF vaccination of Autoimmune Disease patients (AID, n = 140) and Healthy Controls (HC, n = 21). Data interpretation was carried out based on the color keys employed to underscore the baseline fold value = 1.0 as the reference for unaltered levels (black filled square), the baseline fold value < 1.0 for decreased levels (green filled square) and the baseline fold value > 1.0 for increased levels (red filled square), according to the paired sample collected at D0.