Fig. 1. Selected significant gene-trait associations discovered in UKB (UK Biobank) cross-tissue TWAS analysis of 211 neuroimaging traits (n = 19,629 subjects for ROI volumes and 17,706 for DTI parameters).

The gene-level associations were estimated and tested by the cross-tissue UTMOST approach (https://github.com/Joker-Jerome/UTMOST). We used the p value threshold of 1.04 × 10⁻⁸, corresponding to adjusting for testing 211 imaging phenotypes with the Bonferroni correction. The x axis provides the IDs of the neuroimaging traits, and the y axis lists the detected genes in TWAS. The additional (UTMOST new) and previously reported GWAS-significant associations (MAGMA, FUMA, and FUMA&MAGMA) were labeled with different colors (orange, purple, green, and red, respectively).