Fig. 4. Prediction accuracy (incremental R²) of gene-based polygenic risk scores constructed by UKB TWAS results (n = 19,629 subjects) on the four independent data sets.

The x axis lists the four independent cohorts (ADNI, HCP, PING, and PNC) and the y axis lists the ROI volumes. The displayed numbers are the proportions of phenotypic variation that can be additionally explained by UKB TWAS-derived gene-based PRS.