Table 5.

Survey weighted odds ratios (95% CI) for association between serum iron and presence of NAFLD or AHF.

	Quartile for serum iron				P-trend
	Quartile 1	Quartile 2	Quartile 3	Quartile 4
NAFLD
Males
Cases/N	2577/4815	2295/4545	2062/4264	1874/4407
Model 1	1.00 (Ref.)	0.86 (0.77–0.97)	0.78 (0.70–0.88)	0.67 (0.60–0.75)	< 0.001
Model 2	1.00 (Ref.)	0.89 (0.79–0.99)	0.80 (0.71–0.90)	0.69 (0.62–0.78)	< 0.001
Model 3	1.00 (Ref.)	0.89 (0.79–1.00)	0.81 (0.72–0.91)	0.70 (0.63–0.79)	< 0.001
Females
Cases/N	2471/5122	2128/4887	1735/4711	1130/4269
Model 1	1.00 (Ref.)	0.77 (0.69–0.86)	0.55 (0.50–0.62)	0.36 (0.32–0.41)	< 0.001
Model 2	1.00 (Ref.)	0.78 (0.69–0.87)	0.58 (0.51–0.65)	0.39 (0.34–0.45)	< 0.001
Model 3	1.00 (Ref.)	0.78 (0.69–0.87)	0.58 (0.51–0.65)	0.39 (0.34–0.45)	< 0.001
AHF
Males
Cases/N	237/4796	179/4522	131/4235	99/4382
Model 1	1.00 (Ref.)	0.88 (0.64–1.20)	0.76 (0.55–1.06)	0.63 (0.44–0.90)	0.006
Model 2	1.00 (Ref.)	0.92 (0.67–1.26)	0.80 (0.57–1.12)	0.70 (0.49–1.01)	0.031
Model 3	1.00 (Ref.)	0.92 (0.66–1.26)	0.79 (0.56–1.12)	0.72 (0.50–1.04)	0.046
Females
Cases/N	202/5102	198/4869	157/4690	83/4252
Model 1	1.00 (Ref.)	0.80 (0.58–1.10)	0.64 (0.46–0.89)	0.52 (0.35–0.79)	< 0.001
Model 2	1.00 (Ref.)	0.82 (0.59–1.13)	0.70 (0.50–0.98)	0.64 (0.42–0.96)	0.015
Model 3	1.00 (Ref.)	0.81 (0.59–1.12)	0.70 (0.50–0.98)	0.64 (0.43–0.97)	0.018

Model 1: age (years), race (Mexican American, other Hispanic, non-Hispanic white, non-Hispanic black, other race), marital status (married or cohabitation, widowed or separated, never married), education level (less than 12th grade, high school or equivalent, college graduate or above), family poverty income ratio; Model 2: model 1 + smoking status (never, ever, current), alcohol intake (drinkers/week), leisure activity (MET-min/day), total energy intake (kcal/day), healthy eating index-2015; Model 3: model 2 + lead (μg/dL), cadmium (nmol/L).

AHF advanced hepatic fibrosis, MET metabolic equivalent, NAFLD non-alcohol fatty liver disease.